Tag: evolution

Recent Turmoil Accelerates Evolution Of Homebuilding Trends

By Rick Rubin and Will Soper

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Law360 (September 30, 2020, 3:54 PM EDT) —

Rick Rubin
Rick Rubin
Will Soper
Will Soper

All sectors of the construction industry have faced unique challenges in 2020, but perhaps none has been more significantly impacted than homebuilding.

Widespread protests in urban areas, historically cheap financing for single-family homes and the global pandemic have shaped new housing trends and accelerated others.

Personal Space, Not Necessarily More Space

Downsizing had been the story of the decade in housing. The homebuilding industry took notice of empty nesters’ and millennials’ preferences[1] for smaller

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Evolution of radio-resistance is more complicated than previously thought

Evolution of radio-resistance is more complicated than previously thought
Induced radio-resistant E. coli, evolve complex mutation profiles as experimental evolution continues and the level of radio-resistance increases. Credit: Michael M. Cox and coauthors

The toughest organisms on Earth, called extremophiles, can survive extreme conditions like extreme dryness (desiccation), extreme cold, space vacuum, acid, or even high-level radiation. So far, the toughest of all seems to be the bacterium Deinococcus radiodurans—able to survive doses of radiation a thousand times greater than those fatal to humans. But to this date, scientists remained puzzled by how radio-resistance could have evolved in several organisms on our planet, naturally protected from solar radiation by its magnetic field. While some scientists suggest that radio-resistance in extremophile organisms could have evolved along with other kinds of resistance, such as resistance to desiccation, a question remained: which genes are specifically involved in radio-resistance?

To address this question, the team of Dr. Cox, at the University of Wisconsin-Madison,

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Evolution Of The Biotech IPO Markets From Busted To Booming

In the excitement of today’s biotech IPO market, and the bullish period since 2013, it’s almost hard to remember how painful the equity capital markets were back in the day.

When I began my career in venture capital in 2004, the IPO markets were just opening up after the fallout from the bursting of the tech and genomics twin bubbles in 2001. Great companies like Atlas-backed Alnylam and Momenta were going public. Sixteen years later those two are a $15B commercial-stage biotech and a recent $6.5B acquisition by J&J, respectively – very successful biotechs by any measure. But most folks forget that their IPOs were really painful: both priced their offerings ~50% below the mid-point of the expected price range (here, here). This wasn’t an uncommon occurrence.

The IPO markets for most of the 2000s never warmed up much. Jazz Pharma, now a high flying $8B company, “took it on

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Evolution of the COVID-19 vaccine development landscape

The COVID-19 vaccine R&D landscape has developed at unprecedented scale and speed since our initial analysis in April identified 115 candidates in the pipeline (Nat. Rev. Drug Discov. 19, 305–306; 2020). In this updated overview, we focus on candidates in clinical trials and provide some initial perspectives on their clinical development.

Evolution of the R&D landscape

As of 2 September 2020, the global COVID-19 vaccine R&D landscape includes 321 vaccine candidates, an increase of more than 2.5 fold compared with our previous report. Of these, 32 vaccine candidates are in clinical trials (Supplementary Table 1), with plans to enrol more than 280,000 participants from at least 470 sites in 34 different countries. The most advanced clinical candidates are now in phase III trials, and data to support licensure are anticipated to be available later this year. For the leading candidates, large-scale manufacturing of vaccine has already been

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Effects of technology complexity on the emergence and evolution of wind industry manufacturing locations along global value chains

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