Tag: drug

Machine learning model helps characterize compounds for drug discovery

chemical
Credit: CC0 Public Domain

Tandem mass spectrometry is a powerful analytical tool used to characterize complex mixtures in drug discovery and other fields.


Now, Purdue University innovators have created a new method of applying machine learning concepts to the tandem mass spectrometry process to improve the flow of information in the development of new drugs. Their work is published in Chemical Science.

“Mass spectrometry plays an integral role in drug discovery and development,” said Gaurav Chopra, an assistant professor of analytical and physical chemistry in Purdue’s College of Science. “The specific implementation of bootstrapped machine learning with a small amount of positive and negative training data presented here will pave the way for becoming mainstream in day-to-day activities of automating characterization of compounds by chemists.”

Chopra said there are two major problems in the field of machine learning used for chemical sciences. Methods used do not provide chemical understanding

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CU Anschutz campus to get new technology that can cut screening time for new drug therapies in half

AURORA, Colo. (KDVR) — The University of Colorado Anschutz Medical Campus in Aurora announced Tuesday the addition of new technology that researchers say could cut the screening time for new drug therapies in half.

Researchers say the new robotic screening and imaging technology could speed up the development of treatments for COVID, cancer or other diseases, while putting Colorado on the map in this field.

“Similar technologies exist on the coasts in academic institutions, but nothing in this region,” said Dr. David Ross, an associate dean at the CU Skaggs School of Pharmacy and Pharmaceutical Sciences.

He and his colleagues say the machine can take a library with thousands of compounds and quickly screen them against targets in a disease.

“If the disease model took two weeks to screen, we can now screen it in a couple of days,” said Dr. Dan LaBarbera, a researcher who will be using the

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Nvidia Partners With GlaxoSmithKline to Use AI for Drug Development

Nvidia  (NVDA) – Get Report said Monday it was partnering with GlaxoSmithKline  (GSK) – Get Report and its artificial intelligence group to use AI for developing new drugs and vaccines, while building a supercomputer to aid researchers in their work on the coronavirus and other challenges.

Shares of Nvidia, the Santa Clara, Calif.-based computer graphics chip company, were up 3.4% to $540.08, while American depositary receipts of GlaxoSmithKline rose 1.5% to $37.79. 

Located in London, GSK’s hub will use biomedical data, AI methods and advanced computing platforms to unlock genetic and clinical data, Nvidia said.

The GSK AI hub will be home to its U.K.-based AI team, including GSK AI Fellows, a new professional training program and now scientists from Nvidia.

“GSK and Nvidia together will help push the boundaries of what AI can do and put vast data sources to work to advance the discovery

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India’s drug authority approved paper-strip Covid-19 test that could return results within hour

The test, called FELUDA—an acronym for FNCAS9 Editor-Limited Uniform Detection Assay—was named after a popular Indian fictional detective. It intends to “address the urgent need for accurate mass testing,” according to a statement from TATA Sons, which manufactured the test.

The kit could be manufactured for self-testing in the future, according to Agarwal, but the prototype being developed currently is only intended for testing in labs.

The FELUDA test follows a similar rapid test kit developed in the US this spring. Both tests use a gene-editing technology called CRISPR to detect the virus in a patient’s RNA. The US Food and Drug Administration approved the emergency use of the SHERLOCK test kit in May, developed by the Massachusetts Institute of Technology.

The test received approval for commercial launch by the Drugs Controller General of India, the country’s drug authority, on September 19. It had a 96% sensitivity and 98% specificity … Read More

India and South Africa ask WTO to waive rules to aid COVID-19 drug production

FILE PHOTO: A logo is pictured outside the World Trade Organization (WTO) headquarters next to a red traffic light in Geneva, Switzerland, October 2, 2018. REUTERS/Denis Balibouse/File Photo

VIENNA (Reuters) – India and South Africa want the World Trade Organization (WTO) to waive intellectual property rules to make it easier for developing countries to produce or import COVID-19 drugs, a letter here&Open=True to the WTO shows.

In their letter dated Oct. 2 the two countries called on the global trade body to waive parts of the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS), which governs patents, trademarks, copyright and other intellectual property rules globally.

“As new diagnostics, therapeutics and vaccines for COVID-19 are developed, there are significant concerns (over) how these will be made available promptly, in sufficient quantities and at (an) affordable price to meet global demand,” the letter posted on the Geneva-based WTO’s website says.

The

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India and South Africa Ask WTO to Waive Rules to Aid COVID-19 Drug Production | World News

VIENNA (Reuters) – India and South Africa want the World Trade Organization (WTO) to waive intellectual property rules to make it easier for developing countries to produce or import COVID-19 drugs, a letter https://docs.wto.org/dol2fe/Pages/SS/directdoc.aspx?filename=q:/IP/C/W669.pdf&Open=True to the WTO shows.

In their letter dated Oct. 2 the two countries called on the global trade body to waive parts of the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS), which governs patents, trademarks, copyright and other intellectual property rules globally.

“As new diagnostics, therapeutics and vaccines for COVID-19 are developed, there are significant concerns (over) how these will be made available promptly, in sufficient quantities and at (an) affordable price to meet global demand,” the letter posted on the Geneva-based WTO’s website says.

The two countries said that developing nations are disproportionately affected by the pandemic and that intellectual property rights, including patents, could be a barrier to the provision of affordable

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Trump just got a dose of Regeneron’s unapproved antibody drug for covid

The president of the US, Donald Trump, tested positive for the coronavirus and within 24 hours had received an experimental cutting edge antibody treatment not available to other Americans.

In a statement released Friday, the White House said Trump had gotten “a single 8 gram dose” of the biotech treatment, which belongs to a promising new class of virus fighting treatments.

The president “remains fatigued but in good spirits” after getting the emergency infusion, according to White House doctor Sean Conley. “He’s being evaluated by a team of experts, and together we’ll be making recommendations to the President and First Lady in regards to best next steps.”

As the leader of the free world and the head of the US government, Trump and his wife, who also tested positive, were certain to have access to the best medical care the country can provide and experimental drugs not available to others.

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Food and Drug Administration Renews and Expands Use of Certara’s Biosimulation Software for Reviewing Regulatory Submissions

FDA’s Office of Pharmaceutical Quality adds new licenses of Simcyp Simulator

Certara, a global leader in biosimulation, today announced that the U.S. Food and Drug Administration (FDA) has again renewed and expanded its licenses of Certara’s biosimulation software, with more than 400 user licenses of Simcyp™ and Phoenix™ platforms. Eleven divisions and offices of the FDA use Certara’s software for internal research and to independently analyze, verify, and review regulatory submissions.

Certara’s Simcyp Simulator, an industry-leading platform for physiologically-based pharmacokinetic (PBPK) modeling and simulation, is used to determine first-in-human dose, design more efficient and effective clinical studies, and predict drug-drug interactions using virtual populations. The FDA’s Office of Clinical Pharmacology has renewed its licenses for the Simcyp Simulator, including Simcyp Pediatric and the Simcyp Cardiac Safety Simulator. Furthermore, the FDA’s Office of Pharmaceutical Quality recently ordered Simcyp user licenses, expanding the FDA’s use of the platform. The agency uses

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AI Drug R&D Startup XtalPi Announces Over 300 Million Series C Investment Led by SoftBank Vision Fund, PICC Capital, and Morningside

CAMBRIDGE, Mass. and SHENZHEN, China, Sept. 28, 2020 /PRNewswire/ — XtalPi, an Artificial Intelligence (AI) drug discovery and development technology company, today announces an oversubscribed Series C funding of $318.8 million co-led by SoftBank Vision Fund 2i, PICC Capital, and Morningside. The new round of financing is joined by over a dozen global investment companies in banking and technology, with follow-on investments from existing investors Tencent, Sequoia China, China Life, and SIG.

XtalPi Logo (PRNewsfoto/XtalPi Inc.)
XtalPi Logo (PRNewsfoto/XtalPi Inc.)

With the new round of funding, XtalPi will bring the power of quantum physics, AI, and almost limitless cloud resources to propel research scientists towards drug candidates with tailored pharmaceutical profiles. Its platform takes the unique approach of combining physics-based and data-driven models to comprehensively address all drug properties relevant to progression into clinical studies. By integrating the predictions of its virtual R&D platform with real-world data from modern laboratories, XtalPi

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Massive dark web bust seizes $6.5 million from 179 alleged drug dealers

The US Justice Department announced the largest dark web bust it has ever helped carry out, seizing more than 1,100 pounds of drugs from 179 alleged online dealers around the world. The US worked with police in Europe to carry out the investigation, seizing more than $6.5 million in cash and virtual currencies. 



a plastic bag: As part of Operation DisrupTor, the Los Angeles Joint Criminal Opioid Darknet Enforcement team confiscated about 120 pounds of methamphetamine, 15 pounds of MDMA and five firearms in mid-February. Operation DisrupTor


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As part of Operation DisrupTor, the Los Angeles Joint Criminal Opioid Darknet Enforcement team confiscated about 120 pounds of methamphetamine, 15 pounds of MDMA and five firearms in mid-February. Operation DisrupTor

Operation DisrupTor — named after the private web browser Tor frequently used to access the dark web — was led by police in Germany, along with US law enforcement agencies and Europol. 

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The majority of the arrests took place in the US with 121 cases, followed by 42 cases in Germany, eight cases in the Netherlands, four cases in the

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