Tag: Cancers

New methods help to accurately identify cancers’ hidden genetic losses, duplications

Understanding the specific mutations that contribute to different forms of cancer is critical to improving diagnosis and treatment. But limitations in DNA sequencing technology make it difficult to detect some major mutations often linked to cancer, such as the loss or duplication of parts of chromosomes.

Now, methods developed by Princeton computer scientists will allow researchers to more accurately identify these mutations in cancerous tissue, yielding a clearer picture of the evolution and spread of tumors than was previously possible.

Losses or duplications in chromosomes are known to occur in most solid tumors, such as ovarian, pancreatic, breast and prostate tumors. As cells grow and divide, slip-ups in the processes of copying and separating DNA can also lead to the deletion or duplication of individual genes on chromosomes, or the duplication of a cell’s entire genome — all 23 pairs of human

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Merck Advances Oncology Portfolio and Pipeline with New and Long-term Data in Multiple Cancers at ESMO 2020

  • New analyses from Phase III JAVELIN Bladder 100 study of BAVENCIO®* assess efficacy across subgroups, patient-reported outcomes and exploratory biomarkers in advanced urothelial cancer
  • Overall efficacy data, and analyses of brain metastases and HRQoL for tepotinib from largest ongoing study in NSCLC harboring METex14 skipping
  • Long-term follow-up data for novel bifunctional fusion protein targeting TGF-β/PD-L1, bintrafusp alfa, in NSCLC and BTC demonstrate continued durability of response

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Germany, Sept. 14, 2020 /PRNewswire/ — Merck, a leading science and technology company, today announced more than 30 abstracts will be presented at the European Society for Medical Oncology (ESMO) Virtual Congress 2020 from September 19-21. The abstracts span the Company’s clinical program in oncology across several innovative modalities and mechanisms that have the potential to advance treatment

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